Genetic Risk for Lung Cancer and the Benefits of Quitting Smoking
نویسنده
چکیده
Article history: Received 16 August 2016 Accepted 16 August 2016 Available online 18 August 2016 lung cancer risk that is independent of behavior, and therefore, not influenced by quitting. The authors addressed this question using a meta-analytic approach involving 15 studies that examinedmore than 12,000 smokers (Chen et al., 2016). The study found that therewere no differences in the benefits of quitting based on CHRNA5 allelic status. Consistent withmany previ-
منابع مشابه
Genetic risk can be decreased: Quitting smoking decreases and delays lung cancer for smokers with high and low CHRNA5 risk genotypes â•fl A meta-analysis
Genetic risk can be decreased: Quitting smoking decreases and delays lung cancer for smokers with high and low CHRNA5 risk genotypes — A meta-analysis. a b s t r a c t a r t i c l e i n f o Background: Recent meta-analyses show that individuals with high risk variants in CHRNA5 on chromosome 15q25 are likely to develop lung cancer earlier than those with low-risk genotypes. The same high-risk g...
متن کاملGenetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis
BACKGROUND Recent meta-analyses show that individuals with high risk variants in CHRNA5 on chromosome 15q25 are likely to develop lung cancer earlier than those with low-risk genotypes. The same high-risk genetic variants also predict nicotine dependence and delayed smoking cessation. It is unclear whether smoking cessation confers the same benefits in terms of lung cancer risk reduction for th...
متن کاملClinical applications of gene-based risk prediction for lung cancer and the central role of chronic obstructive pulmonary disease
Lung cancer is the leading cause of cancer death worldwide and nearly 90% of cases are attributable to smoking. Quitting smoking and early diagnosis of lung cancer, through computed tomographic screening, are the only ways to reduce mortality from lung cancer. Recent epidemiological studies show that risk prediction for lung cancer is optimized by using multivariate risk models that include age...
متن کاملCYP2A6 genetic polymorphism and its relation to risk of smoking dependence in male Iranians
Introduction: Nicotine is the psychoactive substance responsible for establishing and maintaining smoking dependence. CYP2A6 is the primary enzyme that inactivates nicotine to cotinine .Genetic variation in CYP2A6 accounts for some of the inter-individual variability in nicotine metabolism and has been indicated to influence smoking behavior and dependence. Therefore, the aim of this study was ...
متن کاملSmoking Cessation in Lung Cancer
The greatest risk factor for lung cancer is smoking. Smoking addiction is one of the challenging problems that should be solved in lung cancer patients. Including lung cancer, in cancer patients, quitting smoking has several benefits. However, implementation of smoking cessation clinics in oncology practices is inadequate and many lung cancer patients still smoke despite cancer diagnosis. Multi...
متن کامل